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Treatment of Subacute Spinal Cord Injury
TED-N

Embryonic Stem Cell-derived PSA-NCAM positive Neural Precursor Cells

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Spinal Cord Injury
As an irreversible damage to intraspinal nerve cells, it causes permanent disability.
Cause
Primary: Damage to intraspinal nerve cells due to internal/external factors such as traffic accident or fall
Secondary: Accompanied by serious disability due to inflammation, apoptosis, etc.
Symptom
Fever due to abnormal regulation of body temperature
Motor and sensory disorders, urination disorders, etc. due to paralysis below the injured site
Basic Research Non-clinical Phase 1 Phase 2 Phase 3 Approval
Phase 1/2a
OUTLINE
Therapy
imageInject into damaged spinal cord imagenerve cell
Technology
Embryonic stem cells using TED technology (using DM/SB)
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TED
Cell sorting using PSA-NCAM marker
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PSA-NCAM sorting
DATA
Anti-Inflammation

The anti-inflammation effect was confirmed as one of the mechanisms of action (MoA). Observation of intraspinal microglia (Iba-1) and microglia (ED1) activated by inflammation after the transplant of TED-N in an animal model with spinal cord injury showed that the rate (%) of microglia (ED1) activated by inflammation decreased in the group with TED-N transplant compared to the control group.

  • lba-1 ED1 DAPI Merged

    Control

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    TED-N

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  • 배경 배경
    그래프 그래프

p < 0.0004

Angiogenesis

The angiogenesis effect was confirmed as one of the mechanisms of action (MoA). Observation of angiogenesis factor (Alpha-SMA) after the transplant of TED-N in an animal model with spinal cord injury showed an increase in the group with TED-N transplant compared to the control group.

  • Alpha-SMA DAPI Merged

    Control

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    TED-N

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  • 배경 배경
    그래프 그래프

p < 0.0005

Cell Proliferation

The cell proliferation effect was confirmed as one of the mechanisms of action (MoA). Observation of proliferative cells (BrdU) after the transplant of TED-N in an animal model with spinal cord injury showed an increase in the group with TED-N transplant compared to the control group.

  • BrdU DAPI Merged

    Control

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    TED-N

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  • 배경 배경
    그래프 그래프

p < 0.02

Motor Function Improvement

As a result of evaluating the motor function after the transplantation of TED-N to an model animal with spinal cord injury using BBB score (Basso, Beattie and Bresnahan score), motor function was improved in the group with TED-N transplant compared to the control group.

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