Nerve cells and nervous system cells are difficult to be obtained from adults. However, through the differentiation of embryonic stem cells, it is possible to secure such cell types that couldn't be secured.
A fundamental solution in regenerative medicine can be presented by securing cells identical to damaged ones.
TED technology strictly blocks endodermal and mesodermal differentiation of all embryonic stem cells by controlling two specific signaling pathways (BMP, Activin/Nodal signaling pathway) using two types of small molecules (SB431542, Dorsomorphin). All pluripotent stem cell types including embryonic stem cells can be induced to differentiate consistently and effectively into neural precursor cells by highly effective induction of only the differentiation into the neuroectoderm.
The previously used differentiation methods have shown a wide variation in differentiation yield and the differentiation efficiency was low due to the individual characteristics of each embryonic stem cell line. However, using TED technology, the various differentiation tendencies of each embryonic stem cell line can be overcome and nervous system cells are able to be differentiated from all the embryonic stem cell lines with high efficiency.
Difficult to predict the yield of differentiation into neural precursor cells
Production of highly pure neural precursor cells available from all the embryonic stem cell lines
The pipeline can be expanded by differentiation into various nerve subtype-cells after producing neural precursor cells with high efficiency using TED technology.
① TED - Embryonic stem cell
differentiation standardization
platform technology
Efficient and versatile technology of neural precursor cell (NPC) differentiation from embryonic stem cells
② Expansion of detailed technologies
based on platform technology
Technology of differentiation from the secured neural precursor cells into various
disease-specific cells
③ Pipelines
Development of various cell therapy products
using specific nerve cell types
④ Pipeline expandability