Autologous Dermal Fibroblast Spheroids
|Basic Research||Non-clinical||Phase 1||Phase 2||Phase 3||Approval|
Compared to 2D fibroblasts, FECS-DF has a superior collagenase (MMP-1) and collagen production ability.
The effect of dermal layer remodeling is expected as collagenase (MMP-1) decomposes the old fibrous tissues in the dermal layer and new collagen rebuilds it.
Compared to 2D fibroblasts, FECS-DF(3D) is superior in the production rate of growth factors related to various skin regeneration including PDGFRa, HGF, IGFBP-6, bFGF, VEGF, etc.
The depth, number, and length of wrinkles decreased and the collagen density increased in the FECS-DF injection group 3 weeks after the administration using wrinkle-inducing animal model. The thickness of the thickened epidermis and dermis due to the damage also decreased, which confirmed the effect of significant skin wrinkle improvement.
¶p<0.01, Significant difference from the normal control group(G1) by Student t-test.
** p<0.01, Significant difference from the normal control group(G2) by Dunnett’s t-test.