Human Dermal Fibroblast Spheroid Conditioned Media
Human Dermal Fibroblast Spheroid Conditioned Media
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Human Dermal Fibroblast Conditioned Media is the growth media removed from cultures of human dermal fibroblast spheroids after several days of growth.
Tissue Culture Derivatives
Skin-Conditioning Agents – humectant;
Skin-Conditioning Agents – Miscellaneous
Animal
The ability to secrete growth factors and cytokines that act on cell activity and proliferation and extracellular matrix that provides cell-cell structural and biochemical support is superior when cultivating 3D fibroblast spheroids (FECS-DF) compared to when cultivating 2D fibroblasts.
CFC-FECS-DF shows the superior antioxidant effect to trolox, ascorbic acid, and retinoic acid, which are antioxidants.
A significant wrinkle improvement effect was found with CFC-FECS-DF in a wrinkle improvement test conducted with photoaging-induced model animals.
Pigmentation was induced in animal skin tissues by UVB, and the areas of pigmentation were compared with Hydroquinone (HQ) 1% and Kojic acid (KA) 1%, which have a whitening effect, as positive control groups. As a result, CFC-FECS-DF was found to show a whitening effect similar to that of Hydroquinone 1%, and an improved whitening effect than that of Kojic acid 1%. As for hydroquinone, side effects such as inflammation were found, unlike CFC-FECS-DF.
