Secretome of Embryonic Stem Cell-derived PSA-NCAM positive Neural Precursor Cells
Stroke indicators and active ingredients such as midkine, VEGF, and TGF-β are included.
Stroke was induced by ligation of the middle cerebral artery in the model animals, and the damage induced as such mainly occurred in the cortical and striatal regions of the right brain. A single dose of CF-TED-N to the model animals with stroke showed that the ischemic lesion area was reduced after 14 days.
After the administration of CF-TED-N to model animals, a statistically significant behavioral improvement effect was found in the beam balance test and prehensile traction test compared to the control group; improvement was also found in the line-cross test that measures the decrease of foot faults and activity per unit time. In particular, immediate effects after administration are expected as the improvement effect was confirmed from Day 3 of CF-TED-N treatment in the beam balance test.