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PRODUCTS
Current Pipeline Status Cell Therapy Product Secretome FECS-SOLUTION Cosmetics Ingredient
Treatment of Wounds
CF-FECS-DF

Secretome of Dermal Fibroblasts Spheroids

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Wounds
Damage to skin and subcutaneous tissue due to injury
Cause
Open wounds due to abrasions, lacerations, cuts, penetrating wounds, avulsions, etc. and closed wounds due to bruises, strains, etc.
Symptom
Results in epidermal detachment and bleeding, and causes loss of skin or subcutaneous tissue
Basic Research Non- clinical Phase 1 Phase 2 Phase 3 Approval
Candidate
discovery
OUTLINE
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DATA
Secretion of Wound-healing Factors

Active ingredients in the process of wound-healing such as ENA-78, bFGF, G-CSF, GM-CSF, GROα, IL-6, IL8, MCP-1, RANTES, Serpin E1, μPAR, and VEGF, are included.

  • CF-FECS-DF

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    Media

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  • 1 Angiogenin
    2 CHI3L1, YKL-40
    3 DPPIV
    4 EGF
    5 ENA-78
    6 bFGF
    7 G-CSF
    8 GM-CSF
    9 CXCL1 / CROα
    10 HGF
    11 IL-6
    12 IL-8
    13 CCL2 / MCP-1
    14 MIF
    15 Pentraxin3 / TSF-14
    16 CCL5 / RANTES
    17 Serpin E1
    18 μPAR
    19 VEGF
    1 Angiogenin
    2 CHI3L1, YKL-40
    3 DPPIV
    4 EGF
    5 ENA-78
    6 bFGF
    7 G-CSF
    8 GM-CSF
    9 CXCL1 / CROα
    10 HGF
    11 IL-6
    12 IL-8
    13 CCL2 / MCP-1
    14 MIF
    15 Pentraxin3 / TSF-14
    16 CCL5 / RANTES
    17 Serpin E1
    18 μPAR
    19 VEGF
Promotion of Fibroblast Proliferation

The fibroblast proliferation was promoted more when CF-FECS-DF was treated than when the secretome of 2D fibroblasts was treated on fibroblasts.

배경 배경
그래프 그래프
Wound-healing Ability

It recovers the site where fibroblasts are lost by promoting the proliferation and activity of fibroblasts.

  • Media 2D fibroblast CF-FECS-DF
    Day 0 image image image
    Day 1 image image image
    Day 2 image image image
    Day 3 image image image
    Day 4 image image image

    Loss Site

  • 배경 배경
    그래프 그래프
Angiogenesis Induction

When treating CF-FECS-DF on vascular endothelial cells (HUVEC), more active angiogenesis was induced than when treating an angiogenesis promoter. Angiogenesis helps to heal wounds as it is involved in the formation of new tissues and supplies nutrients and oxygen to growing tissues.

  • Media

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    Boost (bFGF)

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    CF-FECS-DF

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  • 배경 배경
    그래프 그래프